Monitor therapy.Nimodipine 2015, Tartara 1991, Nonsteroidal anti-inflammatory agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. Practitioners Advice Consider taking Ginkgo if you have a family history of senile dementia or Alzheimer’s disease, or if you have senile dementia or Alzheimer’s disease. The leaves of Ginkgo can be used pharmaceutically. Ginkgolic acid and related alkylphenols from the lipid fraction of the fruit pods have been reviewed. Avoid products containing Gingko leaves. Remember This: Circulation stimulation means Brain and Bedroom Boost Reasonable Uses: poor memory, senile dimentia, alzheimers disease, poor memory in the family, alzheimers in the family, as an aid to studying for exams, cold hands and feet, erection problems due to poor circulation. Contact with the fleshy drupe pulp can cause allergic dermatitis similar to that caused by poison ivy.De Smet 1997 Case reports of seizures associated with ginkgo supplementation existGranger 2001; however, ginkgo extracts have been shown to exhibit both anti- and proconvulsant activity in animal experiments.Jahanshahi 2012, Lee 2012, Data have been reported regarding the carcinogenic potential of G. biloba extract, with increased mitosis and cell proliferation observed in some,Wang 2017 but not all, rodent studies.Fernandes 2010, Grollino 2017, Limited clinical studies have also produced equivocal findings. Oddly enough, this ancient tree thrives well in polluted environments, like large cities and roadsides. It has long been revered as a sacred tree in both China and Japan and has featured for thousands of years in traditional Chinese medicine. Additionally, the guidelines state that there is inconsistent evidence supporting the use of ginkgo in the treatment or prevention of Alzheimer disease.Hort 2010 According to a British Association for Psychopharmacology revised (third) consensus statement (2017), until further evidence is available, ginkgo cannot be recommended for either treatment or prevention of Alzheimer disease.O'Brien 2017, The American Academy of Neurology (AAN) practice parameter for the management of dementia (published in 2001, reaffirmed in 2003) states that some patients with unspecified dementia may benefit from G. biloba; however, evidence-based efficacy data are lacking (practice option recommendation).Doody 2001 The American Association for Geriatric Psychiatry position statement for patients with dementia resulting from Alzheimer disease (2006) does not recommend the general use of ginkgo for Alzheimer disease.Lyketsos 2006 The American Psychiatric Association practice guideline for the treatment of patients with Alzheimer disease and other dementias (2007) does not recommend ginkgo for routine use in treating cognitive and functional loss due to uncertainty regarding safety and efficacy.Rabins 2007, Ginkgo extracts have been studied in clinical trials for conditions including schizophrenia, attention-deficit/hyperactivity disorder (ADHD), dyslexia, autism, anxiety, and migraine, with varying results.D'Andrea 2009, Donfrancesco 2007, Lovera 2007, Niederhofer 2009, Savage 2018, Woelk 2007, Yancheva 2009, As an antioxidant, ginkgo is of interest in schizophrenia. It has to be said that Gingko leaves themselves have not been found to be effective in matters of the brain, it is the concentrated extracts made of the leaves that have been found useful. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Herbalists Use It To… Improve memory GBE stimulates blood flow to the brain! It has an angular, dense crown and long branches. QUICK REVIEW History: Used in recent days for poor memory Science: Proven to improve Alzheimer’s Disease Practitioners’ opinion: Works in most cases of senile dementia. After 3-month ingestion of G. biloba extract in one study (N=20), significant (P<0.001) increases in fasting plasma levels of insulin and C-peptide, and in insulin and C-peptide area under the curve (AUC) were observed after a 2-hour 75 g oral glucose tolerance test. The flavonoids act as free radical scavengers, and the terpenes (ginkgolides) inhibit platelet-activating factor. Alternatives Hawthorn(Crataegus monogyna). Stick to products that state clearly they contain standardised concentrated Gingko leaf extracts. Planta Med 1996;62:548-51. A brain, when it gets the oxygen and the glucose it needs, performs better than one that is starved. 4-O-methylpyridoxine has been isolated from the seeds.Liu 2015, Ude 2013, USDA 2018, van Beek 2009, A standardized extract of G. biloba leaves has been examined in several forms of cancer, and numerous mechanisms of action have been proposed based on in vitro studies.Cao 2017, Eli 2006, Li 2002, Liu 2017, Lou 2017, Park 2017, Pretner 2006 Some animal experiments suggest that ginkgo leaf extract reduces the risk of oral cavity, stomach, and colorectal cancer.Ahmed 2017, Chen 2005, Kim 2005, Wang 2000 The deleterious effects of electromagnetic radiation on hippocampal cells were reduced by ginkgo extract given to rats for 1 month,Gevrek 2018 and a protective effect was reported in bleomycin-induced lung fibrosis in rats.Iraz 2006, Conversely, in a mouse colon cancer model, ginkgo exacerbated metastasis to the liver and decreased necrosis and apoptosis of tumor cells.Wang 2017 This is potentially explained by observed carcinogenicity of quercetin in rodents.Wang 2017, Limited clinical studies evaluating use of ginkgo in cancer have produced equivocal findings. Ginkgo needs to be taken for a minimum of 3 months to experience major benefits, and can be taken long term if necessary. Ginkgotoxin, amino acids, cyanogenetic glycosides, and long-chain phenols, including anacaric acid, bilobol, and cardanol, are also present. Occurrence of neurotoxic 4'-O-methylpyridoxine in ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. The fleshy layer and pulp have a foul, offensive odor and can cause contact dermatitis. No changes in glucose tolerance were observed.Kudolo 2000 In a follow-up study of type 2 diabetes patients taking oral hypoglycemic agents, ginkgo increased pancreatic beta cell function in response to glucose loading.Kudolo 2001 Over a 3-month period, the pharmacokinetic properties of metformin 500 mg once daily were not affected by coadministration of 120 mg of ginkgo.Kudolo 2006 Ingestion of 120 mg/day of standardized ginkgo extract for 3 months did not produce insulin resistance in nondiabetic and prediabetic populations, nor did it exacerbate the disease in type 2 diabetic subjects.Aziz 2018, Kudolo 2006, Evidence is lacking regarding the role of gingko in the management of menopausal symptoms or sexual function in women.Reid 2014, Wheatley 2004 Clinical trials with small sample sizes have produced varying and equivocal results regarding effects of ginkgo on sexual function.Ashton 2000, Boone 2005, Oh 2006, Ozgoli 2009, Wheatley 2004 In one study (N=99), G. biloba extract had a small but significant facilitatory effect on physiological, but not subjective, sexual arousal compared to placebo. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Consider therapy modification.Mousa 2010, Spolarich 2007, Stanger 2012, Ulbricht 2008, Salicylates: Ginkgo biloba may enhance the anticoagulant effect of salicylates. Herbalists find that for men suffering from this type of impotence find relief with blood invigorating GBE. Bleeding may occur. For site-specific cancers, there were nonsignificant trends towards an increased risk of breast (HR, 2.15; 95% CI, 0.97 to 4.8; P=0.06) and colorectal (HR, 1.62; 95% CI, 0.92 to 2.87; P=0.1) cancers, and a reduced risk of prostate cancer (HR, 0.71; 95% CI, 0.43 to 1.17; P=0.18).Biggs 2010, Ginkgo seeds have been reported to induce a toxic syndrome ("Gin-nan" food poisoning). Evidence is lacking to support a protective role in cardiovascular conditions and stroke. Pharmacokinetic testing of ginkgo doseforms, including capsules, drops, and tablets, has been conducted. Again, the key to Ginkgo biloba extract’s (GBE) activity is improved blood flow. The major terpene molecules unique to ginkgo are ginkgolides A, B, C, J, and M and bilobalide. In the days of lifestyle drugs that are used to prevent problems and increase the quality of life, gingko is coming into its own. Aging does not take a day off, and for this reason, we shouldn’t take a day off from GBE. The 3 major flavonoids of ginkgo are quercetin, kaempferol, and isorhamnetin. Synonym(s): Salisburia adiantifolia Sm. Warnings Taking too much GBE (more than 240 mg) can cause dermatitis, diarrhea, and vomiting. Little is known about whether it’s safe to use ginkgo while breastfeeding. Scientific Back Up GBE has been shown to sharpen memory, boost concentration, lessen the distressing symptoms of Alzheimer’s disease, and improve circulation to the extremities. Pronunciation: GINK-go bi-LO-ba. Type: Broadleaf. It may also block inflammation and allergic responses, which can contribute to headaches. Family: Ginkgoaceae. Findings from large trials have been pivotal in evaluating the efficacy of G. biloba extracts; however, there is not enough quality evidence to support the use of ginkgo for any indication. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Medically reviewed by Drugs.com. Its incredible adaptability explains why it is still around and the dinosaurs are fossils! There is nothing traditional about GBE or its use. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It is also known as the maidenhair tree because of the resemblance of its bilobed leaves to those of the maidenhair fern. turmeric, saw palmetto, garlic, echinacea. Last updated on Dec 10, 2020. Monitor therapy.Robertson 2008, Nimodipine: CYP3A4 inducers (weak) may decrease the serum concentration of nimodipine. They had tried everything possible for their headaches, but nothing worked until they tried GBE. Ginkgo biloba is a deciduous conifer (a true gymnosperm) that can mature to a whopping 100' tall. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Roasted ginkgo seeds were consumed in ancient China and Japan and were considered a digestive aid and preventive agent for drunkenness. Some patients have reported improvement in as few as seven days. Brought back to America at the end of the 18 th Century, the Ginkgo tree can now be found across America, planted as an ornamental tree often in the same soil where previous trees failed. Standardized ginkgo leaf extracts have been used in clinical trials for cognitive and cardiovascular disorders at daily doses of 120 to 240 mg. Contraindications have not been established. Apart from the symptoms associated with ageing, Ginkgo is also beneficial in the treatment of multiple sclerosis, depression and neuralgia. Ginkgo pollen can be strongly allergenic. Evidence is lacking to support a protective role in cardiovascular conditions and stroke. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Common name: Maidenhair tree (living fossil). Improvements in Mini Mental State Examination (MMSE) score were observed in the combination therapy group; however, changes in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score and the Activities of Daily Living score were not significantly different. AAN guidelines for the treatment of tardive syndromes, including tardive dyskinesia syndrome (2013), conclude that G. biloba extract is probably useful in treatment of tardive dyskinesia syndrome; however, data are limited to inpatients with schizophrenia.Bhidayasiri 2013 For major depressive disorder, the Canadian Network for Mood and Anxiety Treatments clinical guidelines for the management of major depressive disorder in adults (2009) state there is insufficient evidence to provide recommendations regarding use of gingko.Ravindran 2009, The AAN guideline on complementary and alternative medicine in multiple sclerosis (2014) advises that ginkgo is possibly effective for reducing short-term fatigue (low-quality evidence) and is ineffective for improving cognition (high-quality evidence).Yadav 2014, A limited number of small trials evaluating use of ginkgo in diabetes have been conducted. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It is common in the southern third of the country. Indeed, evidence suggests that GBE has the ability to boost brain function on a number of physiological levels. This information relates to an herbal, vitamin, mineral or other dietary supplement. On the impotence front, Gingko is seen as an impotence aid because it increases circulation, to the brain and to points further south. Results of 2 large clinical trials have been published: the GEM study (N=3,069) and the GuidAge study (N=2,854). The foul-smelling odor of the fleshy portion of the seedcoat is caused by high concentrations of butanoic and hexanoic acids. Those looking to avoid diminished mental capacity and those that find they are loosing mental capacity need to know about Gingko, or more specifically Gingko biloba extract(GBE long term). Dutch: Ginkgo, Tempelboom, Waaierboom, Japanse notenboom (this last name originates from the idea that the tree came from Japan and the seeds resembled nuts, but now we know this is incorrect and the name is not in common use). Botanical name: Ginkgo biloba: Family: Ginkgoaceae belong to the class of the Ginkgophytes. Findings from large trials have been pivotal in evaluating the efficacy of G. biloba extracts; however, there is not enough quality evidence to support the use of ginkgo for any indication. In a Word: Keep Your Marbles Plant Uses: Senile dementia, Alzheimer’s, Poor Memory. Common Name(s): maidenhair tree [English] common ginkgo [English] Taxonomic Status: Current Standing: accepted ... Ginkgo biloba : Source: NODC Taxonomic Code, database (version 8.0) Acquired: 1996 : Notes: Reference for: Ginkgo biloba, maidenhair tree [English] It works in the short term and in the long term. Pregnant women should always consult first with a health care professional before taking any treatment. Consider therapy modification.Mousa 2010, Spolarich 2007, Stanger 2012, Ulbricht 2008, Vitamin K antagonists: Ginkgo biloba may enhance the adverse/toxic effect of vitamin K antagonists. Ginkgo biloba is a deciduous Tree growing to 30 m (98ft) by 9 m (29ft) at a slow rate. This class constituted the link between the ferns and the angiosperms (flowering plants). Description: Gingko is a deciduous, large tree, growing to 30 meters tall. Ginkgo biloba L.. Common Name: Maidenhair Tree Family: Ginkgoaceae Engl. Injectable forms of ginkgo may cause circulatory disturbances, skin allergy, or phlebitis; parenteral ginkgo was withdrawn from the market because of the potential for severe adverse reactions.De Smet 1997 Ginkgo products have been implicated in reports of hepatic injury collected between 2004 and 2013 by 8 US centers in the Drug-induced Liver Injury Network.Navarro 2014 Ginkgo pollen can be strongly allergenic. The leaves of the Ginkgo tree, the part used in herbal medicine, are harvested in early autumn before they start to fall. Approximately 40 minor flavonoids have also been identified, including catechins, dehydrocatechins (proanthocyanidins), and flavones (eg, ginkgetin, amentoflavone, bilobetin, sciadopitysin). This is only a brief summary of general information about this product. The report will display the kingdom and all descendants leading down to the name you choose. Common Name(s): 'Bryson City' Ginkgo; Ginkgo; Maiden Hairtree; Phonetic Spelling GING-ko bi-LOW-buh This plant has low severity poison characteristics. Male trees older than 20 years blossom in the spring, and adult female trees produce plum-like, yellow-brown drupe that fall in late autumn. Evidence is lacking to support a protective role in cardiovascular conditions and stroke. See below Description. Its leaves and seeds have been used in traditional Chinese medicine for centuries. When it comes to dementia and memory loss, clinical trials have well established that Ginkgo makes a difference. Some planted trees at temples are believed to be over 1,500 years old. Long used primarily by the elderly, GBE’s use in now extended to young people suffering from poor memory. The name Ginkgo comes from the Japanese words gin, “silver”, and kyo, “apricot” and refers to its silvery apricot like fruit. Mitigate migraines GBE helps prevent the initial vasoconstriction and ischemia (blood deficiency) that initiates a migraines. In one study, GBE reduced headaches in 80% of the people who took it, most of whom were having migraines regularly. Herbalists believe that GBE gently dilates blood vessels, improving blood delivery by arteries and tiny capillaries alike. Information regarding safety and efficacy in pregnancy and lactation is lacking. Ginkgo has been studied extensively in diverse medical conditions. General Information: The Ginkgo is the last member of a family of trees common in prehistoric times, and was, in fact, thought to be extinct in the wild until rediscovered in the 17th century in eastern China. Common name: Ginkgo . The dioecious ginkgo is the world's oldest living tree species. Severe adverse reactions are rare; possible reactions include headache, dizziness, heart palpitations, and GI and dermatologic reactions. A recent study indicates that it can be used by anyone needing to improve their memory and this included a student cramming for an exam. The edible inner seed resembles an almond and is sold in Asian markets.USDA 2018, WHO 1999, The ginkgo species almost became extinct during the last ice age that began approximately 2 million years ago. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. It might cause early labor or extra bleeding during delivery if used near that time. The GEM study (N=3,069 elderly men and women) preplanned an evaluation of cardiovascular outcomes and found no evidence that ginkgo 240 mg/day reduced total or cardiovascular mortality or cardiovascular events.Kuller 2010 A statistically significant positive finding was obtained for ginkgo in peripheral vascular disease; however, the number of events was too small to make any generalizations.Kuller 2010 Similarly, ginkgo did not reduce blood pressure in hypertensive or normotensive participants in the GEM study.Brinkley 2010 A 2009 Cochrane meta-analysis of 14 clinical trials evaluating the role of ginkgo in intermittent claudication found no evidence of a clinically important benefit in patients with peripheral arterial disease; the 2013 update reinforced this conclusion.Nicolaï 2009, Nicolai 2013 The American College of Cardiology Foundation/American Heart Association guidelines for the management of peripheral artery disease (2005/2011) state that the effectiveness of ginkgo in improving walking distance for patients with intermittent claudication is marginal and not well established (level B evidence).Anderson 2013, A Cochrane systematic review of studies to 2005, including 10 trials (N=792) assessing the efficacy of ginkgo, found no convincing evidence to support the use of ginkgo for recovery after stroke or for improvement in neurological deficit at the end of treatment.Zeng 2005, In a double-blind, randomized, placebo-controlled trial (N=102), significantly more patients in the ginkgo group achieved a 50% reduction in 4-month poststroke follow-up National Institutes of Health Stroke Scale (NIHSS) score compared with baseline than those in the placebo group (58.6% vs 18.5%, respectively; P<0.05).Oskouei 2013 In contrast, multivariate regression analysis of the trend of NIHSS scores from admission to follow-up revealed a significant decline in scores for G. biloba when adjusted for age and gender (P<0.05).Oskouei 2013. 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